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[64Cu]IS1051
- Development stage
- Unknown
- Lead developer
- iSeek Biopharma
- Modality
- Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
[64Cu]IS1051 (LEUKOPET) is an investigational, immune-targeted PET radiopharmaceutical developed by iSeek Biopharma. It is a radioactive small-molecule ligand designed to bind specifically to lymphocyte function-associated antigen-1 (LFA-1), a leukocyte surface integrin that plays a key role in immune-cell adhesion and migration. By targeting LFA-1 on activated leukocytes, [64Cu]IS1051 enables the non-invasive, real-time visualization and localization of immune cell trafficking at sites of active infection and inflammation. The candidate is being evaluated in the PUREVIEW First-in-Human Phase 1 clinical study to assess its safety, tolerability, biodistribution, and diagnostic utility in patients with suspected bacterial infections.
- Brand names
- LEUKOPET
- Other names
- [64Cu]-IS1051copper-64 IS1051copper64 IS1051copper 64 IS1051
02
Targets
LFA-1 (Integrin αLβ2)
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